Dried Whole Plant Artemisia annua as an Antimalarial Therapy
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منابع مشابه
Dried Whole Plant Artemisia annua as an Antimalarial Therapy
Drugs are primary weapons for reducing malaria in human populations. However emergence of resistant parasites has repeatedly curtailed the lifespan of each drug that is developed and deployed. Currently the most effective anti-malarial is artemisinin, which is extracted from the leaves of Artemisia annua. Due to poor pharmacokinetic properties and prudent efforts to curtail resistance to monoth...
متن کاملArtemisia annua as a Traditional Herbal Antimalarial
A. annua is so named because it is almost the only member of the genus with an annual cycle. It is a shrub, often growing over 2 m high (Ferreira et al., 1997; see Figure 3.1 and Figure 3.2). Its leaves and flowers contain artemisinin, first isolated in China in 1971; this is the constituent with the greatest antimalarial activity (see Table 3.3). Artemisinin has been found in only two other sp...
متن کاملDried whole-plant Artemisia annua slows evolution of malaria drug resistance and overcomes resistance to artemisinin.
Pharmaceutical monotherapies against human malaria have proven effective, although ephemeral, owing to the inevitable evolution of resistant parasites. Resistance to two or more drugs delivered in combination will evolve more slowly; hence combination therapies have become the preferred norm in the fight against malaria. At the forefront of these efforts has been the promotion of Artemisinin Co...
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An efficient in vitro propagation system for an elite clone EC-353508 of Artemisia annua L., an important antimalarial drug plant has been developed. The best organogenic response, including adventitious multiple shoots and their elongation, was obtained when nodal explants were cultured on MS medium supplemented with 10μM 2-isopentenyl adenine (2iP). An average of 17.7±0.88 shoots with an aver...
متن کاملDomestication of Artemisia annua Plant and Development of New Antimalarial Drug Arteether in India*
Malaria is one of the world 's most devastating human infectious disease and, In India, it is endemic with the mortality rate steadil y increasing. As a result the search for the development of new and more effective chemotherapeutic agents to control this life threatening disease is going on at several centres. In this context, artemisinin isolated from the Chinese herb qinghao (Artemisia annu...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0052746